The album contains features from Wiz Khalifa, Juicy J, Tyler, the Creator, Anderson .Paak, Tay Walker, Dash, King Chip, Mac Miller and JMSN, among others.

[11] David Jeffries of AllMusic said, "Domo Genesis still talks about weed and weirdness, and sometimes with a star-studded guest list, as the killer "Go (Gas)" features Wiz Khalifa, Juicy J, and Tyler, The Creator.

Mac Miller figures into the great "Coming Back", but the bits about Domo's family, his autistic brother, and his own search for self make this a meatier album than expected.

"[12] Keith Nelson Jr. of HipHopDX said, "It's the subtle sequencing--deliberate to show his progression--that elevates the project from merely a delinquent to being the tale of a reformed man.

"[14] Sheldon Pearce of Pitchfork said, "Sometimes the hooks on Genesis get wonky, there are portions of the record that feel unfinished (like the second half of "Wanderer"), and every now and then Domo will sneak in a groaner.