Unlike the 2/3" 3-CCD imaging system used in Sony's HDW-F900 CineAlta camera (used in Attack of the Clones), the Genesis uses a single 12.4 megapixel CCD chip with the same width as a Super 35 mm film frame.
In cases where the lens does fit, the resulting optical aberrations created by the prism (primarily spherical) would destroy image quality.
Apart from this, the sensors on a "2/3 inch" video camera are closer in size to a 16 mm film frame and so would produce a similar depth of field.
Panavision originally tried to overcome this problem with optical adaptors that fit between the cine lens and the video camera, but these have all produced an unacceptable drop in image quality.
The Genesis can record in a custom Panalog color space, using a log tone-curve to preserve highlight detail that would be lost with typical video gamma correction.
[3] Television series shot with the Panavision Genesis include Scrubs, Californication, Outsourced, United States of Tara, Mercy, Stargate Universe, Night Stalker, Conviction, What About Brian, Justice, 3 Lbs., Cranford and 90210.