Genesius is considered the patron saint of actors, lawyers, barristers, clowns, comedians, converts, dancers, people with epilepsy, musicians, printers, stenographers, and victims of torture.

Intending to expose Christian religious rites to ridicule by his audience, he pretended to receive the Sacrament of Baptism.

His relics are claimed to be kept in San Giovanni della Pigna, Santa Susanna di Termini, and the chapel of St. Lawrence.

[5] A Genesian Theatre in Sydney, Australia hosts six seasons each year and is the centre of a vibrant amateur acting community.

Other amateur companies around the world also use his name, including the Genesius Guild of Hammond, Indiana, which hosts an average of four productions each year and an annual children's theater camp, the Genesius Theater of Reading, Pennsylvania, basis for the Lincoln Center production of Douglas Carter Beane's "Shows for Days"[6] starring Patti LuPone, Saint Genesius Productions of Villa Park, Illinois, a youth theatre group that aims to build leadership and community through the theatre arts.

Genesius Studios, a film production company in New York, New York founded by a group of traveling actors, whose slogan is "Freedom of Thought" and whose focus is producing motion pictures with wayward, lost protagonists and anti-heroes who often find something inside themselves worth standing for in tales of self-discovery, hubris and redemption, among other notably relative themes, and the Genesius Guild and Foundation in the Quad Cities in the United States, which focuses on classical Greek Drama.