Our analysis of haplotype similarity at the SLC24A5 region [which affects skin pigmentation] between the Gujarati Indians also indicated greater degree of sharing with the southern Europeans than with the south Tamil Indians.One of the GIH subgroups fall outside the main gradient of Indian groups, suggesting that they harbor substantial ancestry that is not a simple mixture of ASI and ANI.
[16][17] The study by Quintana-Murci et al. (2004) found presence of haplogroup W (8.8%) in Gujaratis as well as other northwestern states like Punjab and Kashmir.
[18][19] A set of 48 bi-allelic markers on the non-recombining region of Y chromosome (NRY) were analysed in 284 males; representing nine Indo-European speaking tribal populations of South Gujarat.
The phylogenetic analysis revealed 13 paternal lineages, of which six haplogroups: C5, H1a*, H2, J2, R1a1* and R2 accounted for a major portion of the Y chromosome diversity.
This implies that although language plays a vital role in determining the distribution of Y lineages, the present day linguistic affiliation of any population in India for reconstructing the demographic history of the country should be considered with caution.
R1b, the most common haplogroup in Western Europe, has a relatively low concentration in India, and it possibly originated in the Persian Gulf.
It is probably originated through random genetic drift in reproductively isolated community, maintained by strict endogamy based on religious and linguistic affiliations.
[25] Rasheedunnisa Begum et al. conducted genetic studies of over 1500 patients from Gujarat and found an SNP variation in the autosomal DNA of Gujaratis which make them more prone to Vitiligo.
[28] The Leicestershire Perinatal Mortality Survey for the years 1976 to 1982 found high incidences of Meckel syndrome in Gujarati immigrants.
One such gol known as Chha Gaam Patels (CGP) include people from six villages of Charotar region of Gujarat.
Due to high diversity in Y-DNA and mtDNA lineages, the strong drift effect is unlikely even though they had small population.
The studies suggest a male-mediated migration of Parsi ancestors from Iran to Gujarat where they admixed with local female population which ultimately resulting in loss of Iranian mtDNA.
[17] Dawoodi Bohras of Gujarat show 47% genetic contribution from West Asia, especially Iran; followed by 30% from Arabia and from 23% closest Hindu parental populations.
[31] Four tribal populations (Chaudhari, Vasava, Kotwalia and Gamit) of the Surat district in South Gujarat were studied for the distribution of 22 polymorphic systems of the blood.