The first OVA is centered around a young girl named Elaine and details the development and creation of a "Genocyber", an ultimate biological weapon created by combining the powers and consciousness of two psychic sisters.
The project is directed by a mad scientist and funded by the Kuryu Group, a huge Japanese corporation that is a world leader in military research.
In the ensuing battle, in which the scientist is killed, huge fires are started, and numerous buildings are heavily damaged, Genocyber also destroys the cyborg agents.
The next morning, Elaine finds that her only friend, a young homeless boy called Rat, whom she met before she was captured, has died after falling from a construction site, likely having been dropped by Wakayama, one of the Kuryu cyborgs.
Elaine becomes filled with anger and screams, turning into Genocyber, and initiating a massive explosion which completely destroys Hong Kong, leaving only a barren wasteland in its place.
In response, the United States agrees to deploy a Carrier strike group to support offensive operations against Karain.
However, satellite photographs have identified an unknown superweapon believed to have been deployed by Karain (in fact, the image is of Genocyber, which destroyed several helicopters after they attacked and killed Elaine's friends).
Realizing that the image is of Genocyber (although this is kept secret), the Kuryu Group agrees to send a team of its top scientists to the Alexandria.
The Kuryu scientists, including the mentally unstable Sakomizu, bring on board a newly created Vajra, anticipating that the fleet will encounter Genocyber.
Alarmed, the Vajra's fighter veers wildly off course in pursuit of the scout plane, entering into a steep dive and narrowly avoiding crashing into the carrier.
The scout plane is forced to make a crash landing on the carrier deck, although Elaine survives unscathed and is taken into the care of the crew.
To Myra, Laura/Elaine reminds her of her own daughter (also named Laura) who died in the plane crash depicted in the first episode of the OVA, when Genocyber was fighting with the Kuryu cyborgs.
The ship's crew, unaware of what actually happened, simply conclude that Sakomizu's Vajra has malfunctioned again and blame him for the incident (once again, Elaine survives without injury).
However, Sakomizu, upon seeing his Vajra destroyed, is insulted and wrongly concludes that the crew sabotaged his work, although he now clearly suspects that Elaine is more than she appears to be.
Genocyber then rises in the sky and spreads its wings, confirming that Karain has suffered a similar fate as Hong Kong.
The episode ends with Genocyber flying away, as Myra, who has been driven to madness by the events, yells for Elaine, who she now truly believes to be Laura, to come back to her.
The fourth OVA onward are much different from its previous ones in terms of setting, taking place in a post-apocalyptic earth, in a region called the City of the Grand Ark.
In a brief opening scene, the now-extremely elderly leader of the Kuryu Group is seen looking at a wall of computer screens that show Genocyber on a rampage of destruction.
The next scene, apparently set further into the future, shows a massive space station, possibly a colony ship, orbiting Earth.
They arrive in Ark de Grande City but, as members of the lower class, are unable to get the medical help necessary to allow Mel to see again.
However, the man tricks Ryu (who is blindfolded) into throwing knives at a real person who is tied to a wall, killing him, much to the delight of the spectators.
Mel, who appears to be in some sort of cocoon, asks Diana for help, stating that if she dies, the child she is carrying will never be born.
As Mel opens her eyes, she hears Diana's voice calling, "Big sister...", and the scene turns to the ruined body of Genocyber, while a baby is heard crying in the background.
Elaine: A young mute girl who seems to be innocent in appearance, but when merged with her less powerful counterpart, she becomes Genocyber, capable of mass destruction as seen in all three OVAs.
Diana's body is completely artificial, except for her head, due to Kenneth Reed's harsh experiments on her, so that she could control Elaine and her Vajra energy.
Myra eventually survives the carrier's destruction thanks to Genocyber's protection, and is later rescued by two Karain soldiers though her sanity is well and truly lost by that time.
She eventually dies at one point in the third OVA, along with the entire underground sect, but then is brought back to life by Genocyber when she and the two sisters fuse together as she states in the hyperdimensional mandala scene, "I want this city destroyed."
(This Vajuranoid seems to be disobedient, like Elaine, and does things by its own free will) He succeeds in creating a powerful Vajra, but it proves to be no match for Genocyber in combat.
He is also eventually fused with the ship's vajuranoid, and dies in the end with the entire crew when Genocyber emits its great power.
Justin Sevakis from Anime News Network stated that the OVA "takes sadistic glee in being as graphic as possible" and "you have to be able to appreciate anger, the sort of nihilism and angst that fills and infects one's soul".