Genovefa von Weber (née Brenner; 2 January 1764 – 13 March 1798) was a German opera singer and actress.

At the time she was born, the castle in Oberdorf was the summer residence of Prince-Bishopric of Augsburg, Prince Clemens Wenceslaus of Saxony.

She was the fourth child of Marx Brenner, a carpenter working at the Prince Bishop's court, and Maria Victoria Hindelang.

On 20 August 1785, at the age of 21, Genovefa married the 51 year old Franz Anton von Weber (1734-1812) at Schottenkirche, a parish church in Vienna.

In 1794, Genovefa appeared regularly as a singer in several roles at Johann Wolfgang von Goethe's theater in Weimar.

On 5 September 1794, Franz Anton sent a letter from Rudolstadt to Goethe, requesting his wife's early dismissal from her contract.

She did not have the opportunity to experience Carl Maria's first published work, a series of six fughetta for piano, which he wrote at the age of 12, the same year she died.

Her memorial is located at the cemetery of St. Sebastian, Salzburg in an artificial "family grave" of Mozart, created by Johann Evangelist Engl in 1901.