The Reverend William Rutter Dawes conducted his noted investigations of double stars at the observatory from 1839 to 1844; John Russell Hind began his career there in October of the following year.

From the time that Karl Ludwig Hencke's detection of Astræa, 8 December 1845, showed a prospect of success in the search for new planets, the resources of Bishop's observatory were turned in that direction, and with conspicuous results.

Between 1847 and 1854 Hind discovered ten minor planets at the observatory, and Albert Marth one.

Other notable astronomers to use the observatory included Eduard Vogel, Charles George Talmage, and Norman Robert Pogson.

[citation needed] Regent's College London now stands on the site of the observatory.