George Donoghue O'Brien (January 1, 1900 – October 25, 1957) was a politician from the U.S. state of Michigan who served as a member of the U.S. House of Representatives on three separate occasions.

During the First World War, O'Brien served as a private and was assigned to the Students' Training Corps.

In 1936, O'Brien defeated incumbent Republican U.S. Representative Clarence J. McLeod to be elected as a Democrat from Michigan's 13th congressional district to the 75th Congress, serving from January 3, 1937, to January 3, 1939.

In 1946, he lost to Republican Howard Aldridge Coffin, but defeated Coffin in 1948 to be elected to the 81st Congress and subsequently re-elected to the 82nd and 83rd Congresses, serving from January 3, 1949, to January 3, 1955.

After leaving Congress, O'Brien served as assistant corporation counsel of the District of Columbia, assigned to the Civil Proceedings Division from July 11, 1955, until his death in Washington, D.C.