George Glass was the founder, President, and Vice Chairman of Pacific Crest Securities, a technology focused investment bank in Portland, OR, from 1990 to 2014.

In 2017, George Glass was nominated by President Donald Trump[3] to become Ambassador Extraordinary and Plenipotentiary of the United States of America to the Republic of Portugal.

[6] During his tenure as Ambassador, Glass has sought to increase economic activity between the United States and Portugal,[7] including on agricultural and energy issues.

[10][11] An editorial in Público referred to the threat as a diktat and an ultimatum;[12] Foreign Minister Augusto Santos Silva reacted to these remarks by asserting that "in Portugal, the decision-makers are the Portuguese authorities, who decide which are Portugal's interests, within the framework of the Constitution and Portuguese law,"[13] and a similar message underscoring national autonomy was issued by President Marcelo Rebelo de Sousa.

[20] Shortly before he left the post, he was awarded the Order of Prince Henry the Navigator by President Marcelo Rebelo de Sousa, during a ceremony at Belém Palace.