Colonel George Fane JP DL MP (c. 1616 – April 1663) was an English politician who sat in the House of Commons at various times between 1640 and 1663.
George Fane was the fifth but fourth surviving son of Francis Fane, 1st Earl of Westmorland and his wife, Mary Mildmay (died 1640), daughter and heir of Sir Anthony Mildmay of Apethorpe, Northamptonshire.
In 1640, Fane was elected Member of Parliament (MP) for Callington in Cornwall, a seat controlled by the Rolle family of Heanton Satchville, Petrockstowe.
Fane acquired the mortgage, in trust for his son, of a Thameside Berkshire estate at Basildon House in 1656 in the names of his sister, Rachael Fane (styled Lady Bath) (who may have supplied the money) and his nephew, Charles Fane, Lord le Despenser (later the third Earl of Westmorland and 10th Baron le Despencer).
He was survived by his son Sir Henry Fane, KB and his wife who later remarried.