George Gray (1725–1800) served as a member of the Pennsylvania Provincial Assembly and as its Speaker in 1783.

His father, also named George Gray, had purchased 199 acres of land on both sides of the Schuylkill River in what was then Blockley Township (present-day West Philadelphia) and Moyamensing (present-day South Philadelphia).

In 1748, the younger George Gray became a lieutenant in Company Nine of the Associators, a volunteer militia.

He was the author of "Treason Resolutions", ordering paper currency, for which he was turned out of the Quaker Meeting.

Gray was a signatory to ratification of the United States Constitution by the Commonwealth of Pennsylvania in 1787.