The George H. and Alice Spaulding Cowles House is a historic building located in Osceola, Iowa, United States.

George Cowles was a native of Bentonsport, Iowa who came to Osceola in 1869, and married Alice Spaulding in 1871.

The house was also owned by a local physician and his wife, Dr. Jason and Mary F.Q.

[2] The two-story brick structure follows a rectangular plan, and is capped with a hipped roof and a cupola.

This article about a property in Clarke County, Iowa on the National Register of Historic Places is a stub.