George Hancock was appointed a colonel in the Virginia militia, where he served as aide de camp to Count Casimir Pulaski.
George and Margaret Hancock's daughter, Julia, married General William Clark at Santillane on January 5, 1808, upon his return from exploring the Louisiana Territory with Meriwether Lewis.
The newlyweds lived left Santillane in the spring of 1808 for St. Louis, so General Clark could become the Superintendent of Indian Affairs and Commander of Militia in the Missouri/Louisiana territory.
Hancock, along with his wife Peggy and son George moved on to Fotheringay, selling Santillane to Henry Bowyer.
[3] In 1793, Hancock was elected to the 5th congressional district with 60.47% of the vote, defeating Independents Caleb Munsey and Charles Clay.