[2] On October 10, 2012, Hincapie released a statement on his website acknowledging the use of performance-enhancing drugs and confirming that he had been approached by US federal investigators and USADA about his experiences with doping.

[3] Later that day a statement was released confirming his acceptance of a six-month ban from September 1, 2012, ending on March 1, 2013, along with a stripping of all race results between May 31, 2004, and July 31, 2006.

His father Ricardo, a native of Colombia, introduced him to cycling, and his first race training was in New York City's Central Park.

Throughout his career Hincapie has targeted the cobbled classics of April, specifically the week that begins with the Tour of Flanders, continues mid-week with Gent–Wevelgem, and ends with Paris–Roubaix.

In 2005, Hincapie showed a talent for short individual time trials (ITTs), winning the prologue at the 2005 Critérium du Dauphiné Libéré, placing second three times and third once in prologues in 2006 (including at the Tour de France), and placing second in the short ITT at Three Days of De Panne.

In the 2006 Paris–Roubaix, bad luck struck Hincapie in the cobbled sector of Mons-en-Pévèle, when the steerer tube of his Trek bicycle snapped, leaving him dangling with no handlebars and crashing heavily.

[18] In March, 2017, Hincapie turned to mountain biking and competed in the Masters category at the eight-day Absa Cape Epic stage race in South Africa over 641 km.

Early in my professional career, it became clear to me that, given the widespread use of performance-enhancing drugs by cyclists at the top of the profession, it was not possible to compete at the highest level without them.

"The statement came as the U.S. Anti-Doping agency announced plans to release documents related to doping accusations against Lance Armstrong, a former teammate of Hincapie.

[19] He is married to former runway model and Tour de France podium girl Melanie Simonneau,[20] and they have three children, a daughter and two sons.