George John Karb (February 15, 1858 – May 15, 1937) was the 30th and 39th mayor of Columbus, Ohio and the 27th person to serve in that office.

After four years as mayor, he was elected as Sheriff of Franklin County.

He served Columbus as mayor during World War I and the Spanish Influenza of 1918.

After three consecutive terms in office Karb was defeated in the 1919 mayoral election by James J. Thomas.

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