From there, he played with the Buffalo Bisons (1913–17), Fort Worth Panthers (1918), San Antonio Bronchos (1919), Shreveport Gassers (1920–23) Beaumont Exporters (1923), Tyler Trojans (1924–25, 1927–28), Greenville Hunters (1926), Laurel Cardinals (1929), El Dorado Lions (1930–32).

Over his career in the minors, Jackson batted .297 with 2,453 hits, 443 doubles, 74 triples, and 157 home runs in 2,365 games played.

[2] He stated that whenever he had any down-time, he would throw a baseball against his barn and catch it, or play a pick-up game with the farm hands.

As a member of the Senators, Jackson played with past, and future Major League Baseball players Harry Betts, Orth Collins, Bill Dammann, Tom Gettinger, Billy Kinloch, Jack Ryan, and Elmer Steele.

[2] The Giants signed Jackson, and farmed him out to the Lake Charles Creoles of the Class-D Gulf Coast League, where he was used as a first baseman.

[4] On the season, Jackson batted .281 with 43 hits, six doubles, two triples, and one home run in 44 games played.

Towards the end of the 1910 season, Jackson was sold by the Dallas Giants to the Memphis Turtles of the Class-A Southern Association.

[2] With Memphis that season, Jackson batted .260 with 78 hits, 17 doubles, four triples, and two home runs in 85 games played.

In exchange for allowing the Boston Rustlers to sign Jackson, the Memphis Turtles was given cash considerations, and pitcher Cecil Ferguson.

[2] They also stated that Jackson had an "unassuming disposition", "has all the confidence in his ability", "is fast on his feet", and is a "good waiter".

[10] One month ago if you mentioned the name of George Jackson in the Hub, or, in fact, in most parts of this country, all hands would look with anxious eyes and listen with wide-open ears for some explanation.

Now you can hardly find a fan in the country who cannot tell you not only what his full name is, but where he was born, and how many bases he has stolen since coming into the big show.Jackson joined the Boston club, now renamed the Braves, in March 1912 for spring training.

[11] On May 30, Jackson hit his first MLB home run, which was inside-the-park, against Brooklyn Dodgers pitcher Nap Rucker.

[12] Jackson hit his second career MLB home run on June 17, against Cincinnati Reds pitcher Bert Humphries.

[12] On August 26, during a game against the Pittsburgh Pirates, Jackson hit his fourth, and final home run of the season, which was inside-the-park off of King Cole.

[13] Jackson was also tied for third with Steve Evans, Josh Devore, Jay Kirke, and Mike Mitchell in errors by an outfielder (15).

On May 14, 1913, the Boston Braves traded Jackson to the Buffalo Bisons of the Double-A International League in exchange for Leslie Mannie.

[15] In his first season with Buffalo, Jackson batted .260 with 110 hits, 15 doubles, seven triples, and three home runs in 116 games played.

He re-signed with the Bisons in 1914; and batted .269 with 84 hits, 17 doubles, four triples, and four home runs in 97 games played.

Jackson joined the Fort Worth Panthers of the Class-B Texas League before the start of the 1918 season.

[21] On August 3, Jackson hit a walk-off home run, giving the Gassers a 12–to–9 victory over the Houston Buffaloes.

[23] In 1922, Jackson batted .344 with 141 hits, 28 doubles, two triples, and 10 home runs in 111 games played with the Gassers that season.

[27] However, at the start of the 1929 season, he was hired as the player-manager of the Laurel Cardinals of the Class-D Cotton States League.

[28] Jackson resided in Blum, Texas, with his wife Elizabeth, and their children Finis, Jack, George E., and Evelyn.