Georg Johann II was born in 1586 as the youngest son of Georg Johann I, Count Palatine of Lützelstein.
His father died in 1592, and George John and his brothers succeeded him under the regency of their mother Anna of Sweden.
In 1601 he received the other half of Guttenberg when his brother Louis Philip died.
In 1611 he inherited the County of Lützelstein following the death of his brother Johann Augustus.
George John married Princess Susanne of Pfalz-Sulzbach (6 June 1591 – 21 February 1661), daughter of the Count Otto Henry, Count Palatine of Sulzbach, on 6 June 1613 and had the following children: