George Lorenzo Otis (October 7, 1829 – March 29, 1882) was a lawyer and politician in the U.S. state of Minnesota.

[1] He served as the 14th mayor of Saint Paul, Minnesota, and also in both houses of the state legislature.

[2][3] Otis ran for Governor of Minnesota in 1869 as a Democrat, but lost to Republican Horace Austin, receiving 46.6% of the vote.

He married Mary Virginia Morrison in 1858.

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