At the time of the 1900 United States census, the family was living in Wolf Township, Lycoming County, Pennsylvania.

[5] The 1912 Ohio Wesleyan yearbook, Le Bijou, said the following of Little: Prexy" Little has won distinction as an athlete and a politician.

[8] The success of the 1912 team led to Ohio State's admission to the Big Ten Conference for the 1913 season.

[9] In January 1916, Little was hired as the head football coach at Miami University in Oxford, Ohio, succeeding Chester J. Roberts.

In his four years as Miami's head coach, Little compiled a record of 27–3–2 including 21 games where the opponent did not score.

[13] He also served as the head coach of the Wisconsin Badgers football team during the 1925 and 1926 seasons, compiling records of 6–1–1 in 1925 and 5–2–1 in 1926.

In January 1927, Little stepped down as head coach of the Wisconsin football team to devote his full efforts to his position as the school's athletic director.

[15][16] In December 1931, Little tendered his resignation as Wisconsin's athletic director, effective at the end of the academic year.

[25][26] In December 1953, Little formally stepped down as Rutgers' athletic director and assumed a new position as special assistant to the university president.

[21] Little continued to serve as executive secretary of the National Football Foundation and Hall of Fame until his death in 1957.

[20] In July 1955, Little was one of five coaches (along with Bernie Bierman, Wallace Wade, Matty Bell, and Eddie N. Robinson) inducted into the College Football Hall of Fame.

[27] He was inducted as a coach but also "due to his work in organizing the Hall of Fame and serving as executive secretary.

[29] Little's funeral service was held at Kirkpatrick Chapel on Rutgers campus; he was buried at Picture Rocks, Pennsylvania.