In addition to Space Ghost Coast to Coast and its spin-off program Cartoon Planet, Lowe has made appearances as Space Ghost in Aqua Teen Hunger Force Colon Movie Film for Theaters, The Brak Show (he was also a series regular, providing the voice for Dad), Robot Chicken (among various other characters), Perfect Hair Forever, and other Adult Swim series.

Lowe appeared as Dick, the chief executive officer of the fictional Bebop Cola company, in a live-action segment of the Sealab 2021 episode "All That Jazz."

Lowe also provides voices on multiple episodes of Robot Chicken, his most well-known role being the recurring perverted Unicorn.

Lowe made a special guest voice appearance in the online games AdventureQuest Worlds and Mech Quest for their Friday 13th events in August 2010, in which he takes the role of a park ranger who tells stories around campfires – but is eventually revealed to be a spirit that feeds on fear.

[10][11] In December 2010, as part of the game's one year anniversary event, George Lowe, as himself, became a fightable NPC in EpicDuel, ArtixEntertainment's PvP MMO.

[14] Lowe also has done voiceovers for Cleveland rock station WNCX, the Fox, FX, and FXX television networks, and commercials for Dunkin' Donuts and Capital One.