He served in various administrative positions at the university, rising from chairperson of the Academic Department of Surgery in 1999, Dean of the School of Medicine, Principal of the College of Health Sciences, Deputy Vice-Chancellor in charge of Administration and Finance to Vice-Chancellor in January 2005 after a competitive recruitment process.
He was actively involved in research in male erectile dysfunction, prostate, testicular and penile cancers, circumcision and HIV/AIDs.
At the time he assumed office, apparently staff members never worked, lecturers missed classes and some even lost student examination marks.
[5] By meeting openly with students to discuss their issues, he created a safety valve for ventilation and preventing them from rioting.
[5] In 2016, with his record as a no-nonsense education administrator, he was appointed the Chairman of the Kenya National Examination Council, by President Uhuru Kenyatta.
His immediate task as the Chairman of KNEC was to reform the council to arrest the widespread academic dishonesty and corruption in the administration of national examinations.
[3] George Magoha joined Maseno University in Kisumu County as a professor of surgery to the School of Medicine on 17 January 2023 and was due to start his new role.
[21] In his 12 year tenure at the University of the Nairobi, he served as the Chairman of the Academic Department of Surgery, Dean of the School of Medicine and Principal of the College of Health Sciences.