He played in Major League Baseball for the Chicago White Sox (1911–12), New York Yankees (1915–20), Washington Senators (1921–25), St. Louis Browns (1925), and Boston Braves (1926–27).

Mogridge threw the first no-hitter for the Yankees franchise in 1917 and was a member of the 1924 World Series champions with the Senators.

[2] Mogridge made his professional baseball debut in 1911 with the Galesburg Pavers of the Class D Central Association.

[2] The Chicago White Sox purchased Mogridge from the Pavers in June, and gave him a brief trial in the major leagues in September 1911.

[6] He participated in spring training with the White Sox in 1913,[7][8] and was released to the Minneapolis Millers of the Class AA American Association.

[20] On December 31, 1920, the Yankees traded Mogridge and Duffy Lewis to the Washington Senators for Braggo Roth.

On June 18, the Senators traded Mogridge and Pinky Hargrave to the St. Louis Browns for Hank Severeid.

[29] The Yankees intended to send Mogridge to a minor league team as payment for players acquired during the 1925 season.

[33] The Braves sold Mogridge to the Rochester Tribe of the Class AA International League in June 1927 so that he could become their manager, following the resignation of George Stallings.

[35] The St. Louis Cardinals acquired the Tribe after the 1927 season, incorporating it into their expanding farm system, and bought Mogridge out of the remaining two years on his contract so they could hire Billy Southworth to manage the team.