Their hit singles include "Do You Really Want to Hurt Me", "Time (Clock of the Heart)", "I'll Tumble 4 Ya", "Church of the Poison Mind", "Karma Chameleon", "Victims", "Miss Me Blind", "It's a Miracle", "The War Song", "Move Away" and "I Just Wanna Be Loved".

Boy George was the lead singer of Jesus Loves You between 1989 and 1992 and still performs solo and with Culture Club, who have reformed twice since initially parting ways in 1986.

Outside of music, Boy George's other creative activities involve mixed media art, writing books, designing clothes and photography.

[16] The pop artists that inspired him were Siouxsie and the Banshees, Roxy Music, Patti Smith,[17] and the two major glam rock pioneers, David Bowie, and T. Rex frontman Marc Bolan.

On 25 November 1984, Boy George provided a joint lead vocal role on the Band Aid charity single "Do They Know It's Christmas?"

With Boy George's subsequent drug addiction, the underwhelming performance of their last two albums, a soured romance between band members shrouded in secrecy, and a wrongful death lawsuit looming, the group ultimately disbanded.

[32] In July 1998, a reunited Culture Club performed three dates in Monte Carlo and then joined the Human League and Howard Jones in a "Big Rewind" tour of the US.

On 27 January 2011, Boy George announced to the BBC that there would be a 30th anniversary Culture Club reunion tour sometime later in the year, and that they would be releasing a new album in 2012.

This may have been due in part to the fact that Boy George was prohibited by US authorities from travelling to the United States for several years because of his British drug charges.

Boy George's next single in the UK was "No Clause 28 (Emilio Pasqez Space Face Full Remix)", a protest song against a legal provision (Section 28) introduced by Margaret Thatcher's Conservative government that prohibited the "promotion" of homosexuality by local authorities such as schools.

From March 1990 to April 1991, Boy George presented a weekly chat and music show on the Power Station satellite channel called Blue Radio.

Some recent tracks were shared by Boy George himself in late 2006 and early 2007 on his YouTube account, his three Myspace pages and sometimes on his official site.

In January 2007, Boy George released "Time Machine" on Plan A Records, a song co-written with Ivor Novello Award-winning songwriter Amanda Ghost, who also co-wrote "You're Beautiful" with James Blunt.

Boy George played a special residency at the Shaw Theatre in London from 23 January 2008, followed by a full UK tour.

The American tour which was planned for July/August 2008 had to be cancelled because he had been denied a United States visa due to a pending London court case scheduled for November 2008.

Boy George's 2012 appearances included the Melbourne International Arts Festival in October, both as featured guest DJ and also performing with Antony Hegarty in the festival's presentations of Swanlights, the Museum of Modern Art's musical artwork commission, which had only been performed one night previously, at Radio City Music Hall in New York City.

The album was written by Boy George and long-time writing partners John Themis, Kevan Frost and Richie Stevens.

It was mixed by Dave Bascombe and features a string of guest musicians including DJ Yoda, Kitty Durham, Ally McErlaine, MC Spee and Nizar Al Issa.

[53] In 2015, BBC Four showed Boy George and Culture Club: From Karma to Calamity a film about a 2014 reunion, a new album, and a planned UK–US tour.

[61] In October 2016, Boy George performed David Bowie's "Starman"—nine months after his idol's death from liver cancer—along with the National Health Service choir, as part of Channel 4's Stand Up to Cancer UK programme.

[62] In 2017, Boy George participated in the last season of The New Celebrity Apprentice on NBC, in which he supported the charity Safe Kids Worldwide and came in second place.

[84] As of 2012[update], Boy George has credited his practice of Nichiren Buddhism and chanting Namu Myōhō Renge Kyō for his newfound spiritual strength to remain sober.

[89] In his 1995 autobiography Take It Like a Man, Boy George stated that he was in fact gay, not bisexual, and that he had had secret relationships with punk rock singer Kirk Brandon and Culture Club drummer Jon Moss.

[90] In the 2008 documentary Living with Boy George, he talked about his first realisation he was gay, when he first told his parents, and why men fall in love with one another as well as with women.

[97] In 1986, keyboardist Michael Rudetsky, who co-wrote the song "Sexuality" on Culture Club's From Luxury to Heartache album, was found dead of a heroin overdose in Boy George's London home.

[101] In court on 1 February 2006, the cocaine possession charge was dropped and Boy George pleaded guilty to falsely reporting a burglary.

[104] In March 2023, a settlement was reached by the four original members of Culture Club, who agreed that George, Hay, and Craig would pay Moss £1.75 million, after he had filed a lawsuit against his former bandmates for lost income due to having allegedly been "expelled" from the group in 2018.

[112] In December 2009, while still on licensed release from prison, Boy George made a request to the Probation Service that he be allowed to appear on the seventh series of Celebrity Big Brother (to be broadcast on Channel 4).

Clayton argued that public confidence in the criminal justice system could be undermined if George earned "a lucrative sum" of money and used his appearance on the show to promote his status as a celebrity.

[113] In 2014, Boy George suffered from a haemorrhaged polyp on his vocal cords, resulting in the cancellation of a Culture Club reunion tour.