He attended The Ohio State University, where the Buckeyes went to the NCAA Final Four 1999, and won the Men's Big Ten Basketball Championship in 2000.

In the 1997–98 season for Logan, Reese averaged 20.2 points and 11.6 rebounds per game and was a second-team NJCAA All-American.

[6] In the inaugural NBA Development League draft in 2001, the Columbus Riverdragons selected George Reese in the ninth round (68th overall).

[4] The next season, Reese played in two Continental Basketball Association teams: the Sioux Falls Skyforce (15 games: 9.7 points, 4.2 rebounds, 1.4 assists, 43.2% field goals made) and Idaho Stampede (14 games: 17.4 points, 5.9 rebounds, 1.7 assists, 1.1 steals, 56.2% field goals).

[9][10] Reese has played in the Polish Basketball League from 2004 to 2012, with the PBL team AZS Koszalin from 2007 to 2012.