George Southall Vest (December 25, 1918 – August 24, 2021) was an American diplomat and State Department official.

George Vest was born in Columbia, Virginia, the son of Nancy Margaret (Robertson) and The Rev.

Volunteering for the United States Army after graduation, Vest participated in the North African landings in 1942, and served as a forward artillery observer in the Italian campaign in US Army's advance up the spine of Italy.

He was then Chief of the Private Office for the Secretary General of NATO (Dirk Stikker) from 1961 to 1963.

Vest spent 1972–1973 as chief negotiator to the Conference on Security and Co-operation in Europe, which led to the Helsinki Accords signed in 1975.

Vest returned to Washington, D.C., in 1973 to become Deputy Assistant Secretary of State for Press Relations for Henry Kissinger.

In 1981, President Ronald Reagan nominated Vest as United States Ambassador to the European Communities.