George W. Cole (March 26, 1827 – December 9, 1875) was an officer in the Union Army during the American Civil War.

His wartime commands included the 2nd United States Colored Cavalry Regiment, and he attained the rank of major general by brevet.

[6] In 1857 he moved to Syracuse, where he became a partner in a lumber business, in which he remained active until the outbreak of the American Civil War.

[19] He was charged with murder; defended by Amasa J. Parker, his first trial ended in a hung jury, and he was acquitted at his second on the grounds of "momentary insanity".

[21] In 1874 he moved to New Mexico in search of a drier climate, which was necessitated by injuries and illness related to his military service.