George Wilkins Guthrie (September 5, 1848 – March 8, 1917) served as Mayor of Pittsburgh from 1906 to 1909 and then was United States Ambassador to Japan from 1913 to 1917.

Next, he studied law at the Columbian College for three years, at which point he was admitted to the bar (in Washington, DC and in Allegheny County on November 5, 1869).

[5] Second, the implementation of a water filtration system during Guthrie's term significantly reduced the incidence of typhoid in Pittsburgh.

[6] Guthrie's term was noted for a significant decline in the city's death rate due to improvement in public health.

He is buried in Allegheny Cemetery in Lawrenceville, PA.[10] Guthrie Street in the Pittsburgh neighborhood of Regent Square was constructed in 1910 and named in the Mayor's honor.