He is the author of a best-selling biography of Pope John Paul II, Witness to Hope, and Tranquillitas Ordinis: The Present Failure and Future Promise of American Catholic Thought on War and Peace.

He has received 18 honorary doctorate degrees, as well as the papal cross Pro Ecclesia et Pontifice and the Gloria Artis Gold Medal from the Polish Ministry of Culture.

He currently serves as Distinguished Senior Fellow and Chair of Catholic Studies at the Ethics and Public Policy Center in Washington, D.C. Each summer, Weigel and several other Catholic intellectuals from the United States, Poland, and across Europe conduct the Tertio Millennio Seminar on the Free Society in Kraków, in which they and an assortment of students from the United States, Poland, and several other emerging democracies in Central and Eastern Europe discuss Christianity within the context of liberal democracy and capitalism, with the papal encyclical Centesimus annus being the focal point.

Weigel wrote Witness to Hope, a biography of the late Pope John Paul II, which was also made into a documentary film.

[8] In 2004 Weigel wrote an article in Commentary magazine entitled "The Cathedral and the Cube" in which he used the contrast between the modernist Grande Arche de la Défense, and the Notre Dame de Paris cathedral, both located in Paris, France, to illustrate what he called a loss of "civilizational morale" in Western Europe, which he tied to the secular tyrannies of the 20th century, along with, more recently, plummeting birthrates and Europe's refusal to recognize the Christian roots of its culture.

The article helped to popularize the word Christophobia,[9] a term coined by the Jewish legal scholar Joseph Weiler, in 2003.

This is a theme sounded clearly by Marcello Pera and Cardinal Joseph Ratzinger (from 2005 to 2013 Pope Benedict XVI), in their book Without Roots: the West, Relativism, Christianity, Islam, for which Weigel authored the foreword.