In 2003, Wilson had four 100-yard receiving games, including a career-high 172 yards on nine receptions and a touchdown in the 71-63 seven overtime win at Kentucky.

Wilson was signed by the Buffalo Bills to their practice squad on October 18, 2004, and played his first regular season game on September 11, 2005, against the Houston Texans.

[3] On October 8, 2007, on Monday Night Football, he intercepted Tony Romo and returned it for a touchdown in his first NFL start.

He also serves as the Buffalo Bills representative for United Way Worldwide Team NFL,[9] to recruit one million volunteer readers, tutors and mentors and cut the high school dropout rate in half by 2018.

In his native Paducah, Kentucky, Wilson also hosts an annual Summer SportsFest that benefits his former high school.

He has also headed up a Life Skills Camping Retreat in Nashville to teach leadership, self-esteem and responsibility to youth.

The "George's Jungle" program is another initiative where Wilson personally donates 20 season tickets and meal vouchers to Buffalo Public High School students.

In addition, Wilson also mentored a group for 15 young men from a local community center in Buffalo through the "That's Life" Program in 2009 and still has a strong bond with each one of the boys.

The players in attendance shared stories about their views on faith, signed autographs and posed for pictures with over 700 members of the Buffalo Community.

Foundation has impacted the lives of over 5,000 students within the Buffalo, NY and Paducah, KY School systems since its inception in 2009.

[6] In early 2010, Wilson performed opposite Mary J. Blige in her music video for the song "We Got Hood Love".

[11] He also performed opposite Marsha Ambrosius in her music video for the song "Late Nights & Early Mornings".