[2] The college enrolls over 3,500 students in 30 academic majors within 23 departments.

Robert Plunkett, the first president of Georgetown, oversaw the division of the school into three parts, "college", "preparatory", and "elementary".

The Graduate School of Arts and Sciences first broke off in 1855, but rejoined the college organization following the downturn in admissions caused by the American Civil War, until reestablishment in 1891.

The School of Languages and Linguistics, itself organized out of the School of Foreign Service in 1949, was collapsed into the College in 1995, as the Faculty of Languages and Linguistics, though it maintains its separate programs.

Andrew Sobanet has been the interim dean of the school since July 1, 2024.