[5] In 2008, the first kidney transplant operation in Guyana was performed at the GPHC by US Army medical professionals for training and humanitarian purposes.

By the time of emancipation in 1838, the hospital mainly served poorer Europeans and sailors and saw as few as 30 patients a day, very few of whom were women.

The hospital expanded in 1846 to accommodate the increase in patients of mostly Portuguese descent, who had been brought into the colony to work.

Breakdowns of patient demographics showed that those in the professional class sought medical care elsewhere, but admissions of skilled laborers indicated the hospital was serving more residents of Georgetown.

[10] The expansion of the 1840s continued until the early 1900s, and patients from more walks of life were being treated and the hospital had the capacity to support 700 beds.