She won the inaugural two St Kilda best and fairest awards (sharing the first in a four-way tie) and was selected in the 2021 AFL Women's All-Australian team.
[6] She made her debut against the Western Bulldogs at RSEA Park in the opening round of the 2020 season and was nominated for the 2020 AFL Women's Rising Star award for her 18-disposal performance in that match.
[12][15][16] She was also named as one of four inaugural St Kilda best and fairest winners later that year, alongside Rosie Dillon, Caitlin Greiser and Olivia Vesely.
[26][27] At the end of the season, Patrikios won her second St Kilda best and fairest award ahead of first-year midfielder Tyanna Smith.
[39] She said the following month that she chose not to receive the vaccine because it "wasn't the right time [...] it was so forced upon, and [she] wanted to take a step back and assess it".