At the same time, she studied jazz piano and worked as an instrumentalist and arranger of Hellenic traditional music of oral transmission for ten years.

[1] She was one of the ten selected composers to participate to the IRCAM's Composition and Musical Computing Annual Course and worked with Jonathan Harvey, Brian Ferneyhough, Tristan Murail, Marco Stroppa, Philippe Hurel and Ivan Fedele.

Wrote Le Monde, "the harshness, not to say the savagery, of the vocal dimension (rattles, howls, strangled sounds or obtained by tapping on the throat) is of today's orality (Spiropoulos says he listened to certain types of rock) while electronics, of the virtual siren kind, refer to the 'ancient' civilization of the studio.

[13] In 2019, Le Monde reporte she had created a multimedia performance during the financial crisis of Athens based on a tag found on a wall, called "Eror (The Pianist)."

She has collaborated with choirs (Accentus, Les Cris de Paris, Le Jeune Choeur de Paris), saxophone quartets (Prism, Habanera, Quasar), and soloists (Claude Delangle, Médéric Collignon, Hélène Breschand, Alvise Sinivia, Shigeko Hata, Geraldine Keller, Theophilos Sotiriades, Vincent David, Valérie Joly).

She has also collaborated with conductors such as Laurence Equilbey, David Milnes, Mark Foster, Pierre Roulier, Guillaume Bourgogne, Geoffroy Jourdain, and Nicolas Krüger.