It connects Cleveland and the North Carolina state line, via Helen, Macedonia, and Hiawassee.

SR 75 begins at an intersection with US 129/SR 11 (North Main Street) in Cleveland in White County.

Just outside town, they meet the northern terminus of SR 75 Alternate and enter the Chattahoochee-Oconee National Forest.

The four highways meet the eastern terminus of SR 288 and cross over a portion of Chatuge Lake.

[2] The original southern terminus was at Georgia State Route 254 near the Mossy Creek and Skitt Mountain Golf Courses.

It began at an intersection with US 129/SR 11 (North Main Street) in the north-central part of the city of Cleveland.

It curved to the northwest and met its northern terminus, an intersection with SR 75 (Helen Highway).

is an 11.1-mile-long (17.9 km) alternate route that exists entirely within the central part of White County.

The road continues to the north-northeast and meets its northern terminus, an intersection with SR 17/SR 75, just northwest of Helen.

It curves to a more easterly direction and meets its northern terminus, an intersection with SR 75 (Helen Highway).

State Route 75 is notable for its inclusion in the National Highway System (NHS), but only within the segment shared with US 76/SR 2.

Additionally, SR 75 passes through the picturesque Chattahoochee-Oconee National Forest, providing scenic views and recreational access, especially near the Helen area.