During his ministry he made deep breakthroughs in agricultural policy and successfully handled the issue of land distribution to landless peasants.
In 1920, after the unexpected defeat of the Liberals in the November elections, Kafantaris went abroad, from where he returned in September 1922, after the Asia Minor tragedy and the 1922 Greek coup.
Under 4th of August Regime, Kafantaris was deported to Zakynthos because of his anti-regime activities, and remained there for three years, until the death of Ioannis Metaxas.
After the end of World War II, he fought in vain for national reconciliation and clashed with Georgios Papandreou, whom he held responsible for the Dekemvriana.
Georgios Kafantaris died on 28 August 1946, a few days before the referendum of 1 September 1946, which led to the restoration of the monarchy and the return of George II to the Greek throne.