[4] Geotrichum candidum is closely related to Saprochaeta sp., rarely isolated but may cause invasive and disseminated disease with high mortality yeast-like and mold-like strains have been identified.

[5] The most important risk factor for invasive fungal infection related to Geotrichum is severe immunosuppression, especially in hematological malignancies as acute leukemia, associated with profound and prolonged neutropenia.

[2][6] Fungemia is very common, often with deep organ involvement (lung, liver, spleen, and central nervous system) and also skin and mucous membranes lesions.

[7] There is no optimal treatment for Geotrichum infections but based on existing data guidelines recommend amphotericin B with or without co-administered flucytosine or with voriconazole showing good in vitro susceptibility.

Species of Geotrichum are occasionally mistaken for fast growing members of the genus Dipodascus, which are characterized by irregularly branched, 10–14 μm wide hyphae and the production of single-spored asci.