Signed by the Toronto Blue Jays as an amateur free agent in 1983, he worked his way through the minor leagues.

He returned to the majors in 1992 with the Cincinnati Reds, and the following year was an inaugural member of the 1993 Florida Marlins expansion team.

[1] He spent the next three seasons with the Baltimore Orioles, Cleveland Indians, Detroit Tigers, Blue Jays, and Los Angeles Dodgers.

[1] He played for the Korea Baseball Organization's Lotte Giants in 2002 and the Sultanes de Monterrey of the Mexican League in 2003 before retiring.

[2] On December 20, 2007, Berroa was accused by former major league pitcher Jason Grimsley of using anabolic steroids in a federal agent's affidavit.