He is the co-founder and co-editor-in-chief of the international scientific journal Biomechanics and Modeling in Mechanobiology by Springer Nature since the first issue published in June 2002.

[5] Holzapfel is widely known for his contributions to the fields of nonlinear solid mechanics, constitutive and computational modeling of fiber-reinforced materials and soft biological tissues including blood vessels in health and disease.

Holzapfel's research has mainly focused on nonlinear continuum mechanics, multi-scale constitutive modeling of solids at finite strains including fiber reinforcement, computational methods, fracture, and material failure.

In recent years, he has increasingly directed his attention towards the biomechanics and mechanobiology of soft biological tissues, the cardiovascular system including blood vessels in health and diseases such as aneurysm and aortic dissection, therapeutic interventions such as balloon angioplasty and stent implantation.

Besides his well-known textbook Nonlinear Solid Mechanics: A Continuum Approach for Engineering,[7] two of the constitutive models proposed by his group and longtime collaborator Professor Ray Ogden are now referred to as the hgo [9] and goh [10] models which have been implemented in commercial software such as Simulia Abaqus[11] Holzapfel has received many awards and honors including the following: Holzapfel has authored a graduate textbook and co-edited seven books.