German submarine U-1106 was a Type VIIC/41 U-boat of Nazi Germany's Kriegsmarine during World War II.

She was ordered on 14 October 1941, and was laid down on 28 July 1943, at Nordseewerke, Emden, as yard number 228.

The submarine was powered by two Germaniawerft F46 four-stroke, six-cylinder supercharged diesel engines producing a total of 2,800 to 3,200 metric horsepower (2,060 to 2,350 kW; 2,760 to 3,160 shp) for use while surfaced, two SSW GU 343/38-8 double-acting electric motors producing a total of 750 metric horsepower (550 kW; 740 shp) for use while submerged.

[3] On 29 March 1945, nine days out of Horten, on her first, and only, war patrol, she was located by a British Liberator aircraft of the 224 Squadron RAF/O.

U-1106 was sunk by depth charges in the Norwegian Sea, north of the Shetland Islands, with all 46 of her crew.