German submarine U-426 was a Type VIIC U-boat of Nazi Germany's Kriegsmarine during World War II.

The submarine was powered by two Germaniawerft F46 four-stroke, six-cylinder supercharged diesel engines producing a total of 2,800 to 3,200 metric horsepower (2,060 to 2,350 kW; 2,760 to 3,160 shp) for use while surfaced, two Siemens-Schuckert GU 343/38–8 double-acting electric motors producing a total of 750 metric horsepower (550 kW; 740 shp) for use while submerged.

U-426 then left Bergen on 5 October 1943 and headed for the Atlantic Ocean via the gap between Iceland and the Faroe Islands.

She sank the British ship Essex Lance on 15 October 408 nautical miles (756 km; 470 mi) east of Cape Farewell (Greenland).

On the eighth, she was attacked and sunk by depth charges dropped by an Australian Sunderland flying boat of No.