German submarine U-753 was a Type VIIC U-boat built for Nazi Germany's Kriegsmarine for service during World War II.

The submarine was powered by two Germaniawerft F46 four-stroke, six-cylinder supercharged diesel engines producing a total of 2,800 to 3,200 metric horsepower (2,060 to 2,350 kW; 2,760 to 3,160 shp) for use while surfaced, two Garbe, Lahmeyer & Co. RP 137/c double-acting electric motors producing a total of 750 metric horsepower (550 kW; 740 shp) for use while submerged.

George Calvert was destroyed by three torpedoes off the coast of Cuba, killing three of her fifty-one man crew.

Twenty-five days into her forty-two-day voyage on 22 February, U-753 found the ON-166 convoy in the mid-Atlantic, her target: the Norwegian Whale ship N.T.

Eight days in, she was discovered 10 nautical miles (19 km) away from convoy HX 237 by a Sunderland aircraft of No.

After a twenty-minute exchange of fire with the aircraft, U-753 dove when the corvette HMCS Drumheller joined the engagement.

An aircraft from the escort carrier Biter marked the location of the submarine with smoke flares.

HMS Lagan caught up to the Drumheller and the two dropped depth charges, finally sinking U-753; all 47 crewmen were lost at sea.