His work, Die Africanische auf der Guineischen Gold-Cust gelegene Landschafft Fetu, was one of the earliest sources on life on the Gold Coast, now modern day Ghana.

A year later, the colony of Great Fredericksburg was established to secure the transatlantic slave trade at Cape Three Points, which was sold to the Dutch in 1717.

In the 19th century, German missionaries such as Christian Gottlieb Blumhardt and Franz Michael Zahn were active on the Gold Coast.

In 1921, German missionaries were expelled from the Volta region by the British colonial authorities after World War I.

[2] In 1932, the Kwami Affair occurred when the National Socialist Gauleiter of Weser-Ems and Prime minister of the Free State of Oldenburg, Carl Röver, tried to prevent the sermon of the Ghanaian pastor Robert Kwami on 20 September 1932 in the St. Lambert's Church in Oldenburg.

[3] In 1956, the Federal Republic of Germany (FRG) opened a consulate in Accra, which was converted into an embassy a year later after the official establishment of diplomatic relations with the now independent state of Ghana.

In 1972, Ghana also established diplomatic relations with the German Democratic Republic (GDR) after the end of the Hallstein Doctrine.

Germany aims to support Ghana in achieving the Sustainable Development Goals of the United Nations.

[11] Prominent German-Ghanaians include restaurateur Nelson Müller, dancer and fitness trainer Detlef Soost, singer and TV host Daniel Aminati and footballers Gerald Asamoah, Jérôme Boateng, Kevin-Prince Boateng and Dennis Aogo.

Ghana internationals such as Otto Addo, Hans Sarpei, Prince Tagoe, Tony Yeboah and Isaac Vorsah played in Germany.