The German Foreign Office describes bilateral relations as close and based on mutual trust.

Nevertheless, there are difficult framework conditions for trade and investment, and human rights issues are also raised by the German side.

The Goethe-Institut supports one German reading room each in Tashkent and Samarkand as well as an offer of information materials in Fergana.

In 2007, Germany – which was widely seen as seeking secure energy supplies – pushed for an easing of EU sanctions on Uzbekistan despite the country's failure to improve its human rights record;[2] already in 2006, Germany had waived the EU sanctions to allow the then most senior figure on the banned list – Interior Minister Zokir Almatov – into the country for cancer treatment.

[4] In 2024, both countries signed an agreement to enable the migration of skilled workers from Uzbekistan to support the German economy and the return of some immigrants.

More than 192 million EUR, referring to the period between 2019 and 2020, has been spent by the German government on development projects of Technical and Financial Cooperation with Uzbekistan.