The first stone of the building, designed by architect Raffaele Fagnoni, was laid on March 24,1955; May 15,1960, was consecrated by Cardinal Clemente Micara.

The dedication to Jesus worker was commissioned by the popes themselves as a sign of the Church's presence in the world of work.

The church is a home parish, established on March 12,1955, with the decree "Paterna solicitude"; in 1969 Paul VI awarded her the title of cardinal of "Jesus Divine Worker".

Inside is the chancel floor, a crucifix over a background of multicolored tiles as well as a ceiling of reinforced concrete beams.

Pope Paul VI established it as a titular church on 30 April 1969.