To the southeast of the spire[clarification needed], one can see a block away the Fountain of Monteoliveto and the piazza of the church of Sant'Anna dei Lombardi.

The square is a result of the expansion of the city to the west beginning in the early 16th century under the rule of Spanish viceroy Pedro Alvarez de Toledo.

Political intrigues by the Sanseverino family caused the property to be confiscated, and eventually sold in the 1580s to the Jesuits for 45,000 ducats to construct a church (1584–1601) under architect Giuseppe Valeriano.

The vault frescos, representing biblical and saintly narratives that exalt the name of Jesus, were carried out by Belisario Corenzio and Paolo de Matteis.

From left to right are medallions of Saints Juliana of Liège, Stanislaus Kostka, Thomas Aquinas, Francis Borgia, Gaetano Thiene, and the blessed Lanfranc of Canterbury.

Under the altar there is a bronze urn containing the mortal remains of St. Joseph Moscati (1880–1927), a biochemistry teacher at the University of Naples and head physician of the Ospedale degli Incurabili, canonized on 25 October 1987 by Pope John Paul II.

The left panel shows the professor with his students, the middle the saint enlightened by the Eucharist, the right one the doctor, giving comfort to suffering and sick people at the Hospital.

On the upper part, three paintings on the wall by Luca Giordano and the vault frescos by Corenzio and De Matteis represent episodes from the saint's life.

The Prince of Venosa, Carlo Gesualdo, who was a famous composer and infamous murderer of his wife and her lover, is buried in front of the St. Ignatius Chapel.

[4] The chapel has a wooden statue of Christ crucified, with the Blessed Virgin and St. John, sculpted by Francesco Mollica, a pupil of Michelangelo Naccherino.

[5] The two imposing side Reliquaries, with 70 busts of saint martyrs in golden wood, were made in the most part in 1617 by the Neapolitan woodcarver Giovan Battista Gallone.

The noteworthy monastic courtyard at the rear of the church is the result of renovation carried out by Domenico Antonio Vaccaro in the 1730s, for Maria Amalia of Saxony, wife of Charles III of Bourbon, King of Naples.