"Get Out of Your Own Way" is lyrically addressed to the daughters of lead vocalist Bono[1] (actress Eve Hewson, and Jordan, both featured on the cover),[2] with words of encouragement to not be one's own worst enemy.

[3][4] The lyrics also reference the US political crisis, mentioning Liberty receiving a "smack in the mouth".

[5] Segueing between the end of "Get Out of Your Own Way" and the beginning of the album's next track, "American Soul", is a spoken word segment by rapper Kendrick Lamar; playing what Bono called a "cracked preacher", Lamar gives an ironic take on the Beatitudes.

[7] U2 performed "Get Out of Your Own Way" on the 2 December 2017 episode of American comedy television series Saturday Night Live.

[10] For the 60th Annual Grammy Awards, U2 pre-recorded the performance of "Get Out of Your Own Way" on a barge in front of the Statue of Liberty.