[5] The station served as both a hospital during the battle and hub for outgoing wounded soldiers and incoming resources and supplies following the end of the war.

[12] The station was undamaged during the battle and returned to service in 1865 following the end of evacuation of the wounded or dead and repairs to the lines.

[16] As the Confederate forces approached the town the depot's telegrapher, the adopted young daughter of a "Mr. (Brown) Lee in Washington county, [sic] Pa.", evacuated the station at the beginning of the battle and "took the machine from the operating table [and] connected the wires so as to preserve the circuit intact and carried the instrument to Cemetery Hill" where, after instructing soldiers how to connect to the wires (e.g., along the Baltimore Pike), she used the key to relay Union Army information.

Commercial telegraph service in the depot began in 1866,[verification needed] (L. D. Plank replaced Charles T. Rose as the 1902 Western Union Telegraph operator in the "W. U. office")[19] and the station's railroad line became part of the successor lines: Susquehanna, Gettysburg and Potomac Railway (1870), Hanover Junction, Hanover and Gettysburg Railroad (1874), Baltimore and Harrisburg Railway (1885), and Western Maryland Railway (1917).

[1]: 23  On April 1, 1955, Western Maryland leased the building to the Gettysburg Travel Council (CSX Transportation owned the station in 1987).

4395 by Todd Platts failed in the US Senate for allowing Gettysburg National Military Park acquisition of the depot.