The first ICC tournament for the team was in Division Three of 2006 World Cricket League Africa Region, where it finished in the third place.

[8] Although the sport had been introduced by British settlers, representative teams were multiracial from an early stage – the 1912 Gold Coast–Southern Nigeria fixture, the only pre-war match for which a scorecard is available, featured names like Otoo, Sagoe, Agbokpo, and Akufo (for Gold Coast), and Layode and Oseni (for Southern Nigeria).

[11][12] After a long gap, inter-colonial matches resumed in April 1926, when the Gold Coast played the Nigerian national team in Lagos.

[17] The West Africa Cricket Council was formed later in 1976, with The Gambia and Sierra Leone joining Ghana and Nigeria as members.

[21][22] However, the West Africa Cricket Council lost significance in 2000, when Nigeria applied for separate membership of the ICC.

[24] A 2000 CricInfo article noted that cricket in Ghana was then confined to the south of the country, played only in the capital and the cities of Kumasi and Obuasi.

At the 2006 Africa Division Three qualifier, Ghana placed third behind Mozambique and Sierra Leone, again defeating Malawi in a third-place playoff.

[27] The playoff was noted for the performance of Ghanaian player Peter Ananya (a future national captain), who took 7/25 to bowl Malawi out for 41.

[28] Ghana won the 2008 Africa Division Three tournament by defeating Swaziland in the final, having earlier bowled Rwanda out for 23 in their semi-final.

[32] The only African side at the eight-team tournament, played in Samoa, Ghana lost only two matches, both to Vanuatu, placing runner-up and qualifying for the 2013 Global Division Seven event.

[41] Ghana's first T20I match was against Namibia on 20 May 2019, after finishing top of the North-Western sub-region qualification group, advancing to the Regional Final of the 2018–19 ICC World Twenty20 Africa Qualifier tournament.

[42] In 2021 Ghana was among five teams excluded from the ICC T20I Championship for failing to play enough fixtures in the relevant period, an effect of the COVID-19 pandemic.