The Ghanem family is descended from brothers Jafna ibn Amr and Thalabah ibn Amr of the Azd Dynasty, one of the oldest Pre-Islamic tribes that inhabited southwestern Arabia, mainly Yemen, and the Al-Bahah and 'Asir provinces in Saudi Arabia.
Following the Ma'rib dam break during the 3rd century, they scattered between modern-day Saudi Arabia and the Levant.
Jafna settled in Roman-ruled Syria and initiated the Kingdom of the Ghassanids, which disappeared in 635 when the area was conquered by Muslims.
Meanwhile, his brother, Thalabah ibn Amr, settled in Hijaz and his descendants became the Ansaris, the local inhabitants of Medina who took the Islamic prophet Muhammad and his followers into their homes when they emigrated from Mecca during the Hijra.
In the following centuries, his descendants moved to other regions in Lebanon, including Lehfed, Jouret Bedran, among others.