His family originally came from Albania and the wider region of Epirus and was possibly born in North Macedonia, south of the city of Skopje, in Köprülü (present-day Veles).

In all available historical sources, despite the discrepancies about his exact birthplace, he is always referred to as an Albanian, an indication of his origin's role in the patronage networks which supported his political career.

In the Romanian principalities, Mehmed Pasha promoted an 'ethnicity-based patronage system' and chose to appoint Albanians as a means to strengthen his apparatus in the region.

[10] Ion Neculce (1672–1745), another contemporary Romanian historian who continued the tradition of Miron Costin, recorded a tale about Gheorge Gica and Mehmed Pasha.

Unable to cope with the financial burdens imposed by the Porte, he was dismissed; nonetheless, following the intervention of Mehmed Pasha his son Grigore I Ghica became the new voivode.

Taking advantage of the defeat of the Ottomans at the Battle of Levice (1664), Grigore fled to Poland and then to Vienna, in search of Habsburg military aid.

[13] His son Grigore II Ghica, initiated in the intricacies of the Ottoman politics due to his rank as Dragoman, succeeded in acquiring the Moldavian throne on 26 September 1726.

[11] During his rule in Moldavia, Grigore II Ghica made proof of great diplomatic skills by leveling an unfortunate conflict with the Crimean Khanate who threatened to ravage the country.

Grigore II Ghica's diplomatic skills proved even more remarkable during the Russo-Austrian-Turkish War, when the Prince of Moldavia, at the request of the Porte, acted as the intermediary and mediator between the Ottomans and Russians through correspondence and exchange of envoys with the Russian Field Marshal Burkhard Christoph von Münnich, with John Bell, the secretary of the British embassy in St. Petersburg, with the French ambassador to Constantinople, Louis Sauveur Villeneuve, as well as with the great Ottoman dignitaries.